ANTICANCER PROFILING OF PHYTOCHEMICALS: A STUDY ON MCF-7 CELL LINES
Abstract
Cancer remains a leading cause of global mortality, characterized by genetic mutations that lead to uncontrolled cell proliferation and resistance to conventional therapies. This study investigates the anticancer potential of various phytochemicals as safer, more targeted alternatives or adjuvants to traditional treatments. Objective of this study is to profile the pharmacological attributes and cytotoxic efficacy of diverse plant-derived compounds against the MCF-7 breast cancer cell line. MCF-7 cells were cultured in DMEM supplemented with 10% FBS and treated with various phytochemical concentrations. Cytotoxicity was determined using the MTT [3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide] assay, and IC50 values were calculated. Comparative analysis revealed a wide range of ED50 values, with compounds like Sanguinarine (10 µM), Beta-Carotene (15 µM), and Sulforaphane (15 µM) exhibiting high potency. Key mechanisms identified include the inhibition of the NF-kB pathway, induction of p53 and SOCS proteins, and modulation of the apoptotic index. Phytochemicals demonstrate significant pleiotropic effects on cancer signaling pathways. While some compounds like Curcumin and Resveratrol face bioavailability challenges, their ability to target multiple survival axes makes them promising candidates for future chemopreventive and therapeutic strategies.
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