ANTIOXIDANT, PHOTOPROTECTIVE AND THERMORESPONSIVE NANOEMULGEL BASED ON PLURONIC® F127 AND HYMENAEA COURBARIL EXTRACT

  • Anna Júlia Santos Barros
  • Raíssa Sales Bastos
  • Maria Socorro Pinheiro Silva
  • Caroline Goes Sampaio
  • Nágila Maria Pontes Silva Ricardo
  • Louhana Moreira Rebouças Federal Institute of Ceará
  • Emília M. A. Santos Instituto Federal de Educação, Ciência e Tecnologia do Ceará. Departamento de Química e Meio Ambiente, Instituto Federal de Educação Ciência e Tecnologia do Ceará, Maracanaú-CE, Brasil.
  • Rahul Kaushik Professor, Metro College of Health Sciences & Research, Greater Noida, Uttar Pradesh, India

Abstract

Objective: The objective of the present work was to prepare a thermoresponsive nanoemulgel based on a natural extract extracted from the stem of Hymenea courbaril for photoprotective cosmetic application.


Significance: Topical photoprotection is restricted due to the short half-life of synthetic actives on the skin, which requires frequent reapplications in addition to presenting potential risks of side effects.


Methods: Initially, the Hymenaea courbaril extract was obtained and characterized in terms of total phenolic and flavonoid content. A nanoemulsion based on the extract was prepared and identified and incorporated into a Pluronic® F127 gel to form the nanoemulgel. The antioxidant and photoprotective activity of the nanoemulgel and the extract were determined. The sol-gel transition temperature of the nanoemulgel was identified by tube inversion method. The extract obtained showed a high value of total phenolics and flavonoids. The nanoemulsion containing the encapsulated extract showed values of zeta potential, diameter and polydispersion index compatible with colloidal stability.


Conclusions: The nanoemulgel showed antioxidant and photoprotective activity with an SPF of 2.3 ± 0.1 and thermoresponsive with a sol-gel transition temperature of 23-24 °C, showing promise as a new cosmetic photoprotector that may contain a lower concentration of synthetic actives due to its SPF complementation attributed to Hymenaea courbaril stem extract.

Keywords: Hymenaea courbaril, Antioxidant, Photoprotector, Nanoemulgel, Pluronic® F127

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How to Cite
Barros, A., R. Bastos, M. Silva, C. Sampaio, N. Ricardo, L. Moreira Rebouças, E. Santos, and R. Kaushik. “ANTIOXIDANT, PHOTOPROTECTIVE AND THERMORESPONSIVE NANOEMULGEL BASED ON PLURONIC® F127 AND HYMENAEA COURBARIL EXTRACT”. Journal of Applied Pharmaceutical Sciences and Research, Vol. 6, no. 4, Feb. 2024, pp. 29-35, doi:10.31069/japsr.v6i4.05.
Section
Research Articles

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