ANTIOXIDANT, PHOTOPROTECTIVE AND THERMORESPONSIVE NANOEMULGEL BASED ON PLURONIC® F127 AND HYMENAEA COURBARIL EXTRACT
Abstract
Objective: The objective of the present work was to prepare a thermoresponsive nanoemulgel based on a natural extract extracted from the stem of Hymenea courbaril for photoprotective cosmetic application.
Significance: Topical photoprotection is restricted due to the short half-life of synthetic actives on the skin, which requires frequent reapplications in addition to presenting potential risks of side effects.
Methods: Initially, the Hymenaea courbaril extract was obtained and characterized in terms of total phenolic and flavonoid content. A nanoemulsion based on the extract was prepared and identified and incorporated into a Pluronic® F127 gel to form the nanoemulgel. The antioxidant and photoprotective activity of the nanoemulgel and the extract were determined. The sol-gel transition temperature of the nanoemulgel was identified by tube inversion method. The extract obtained showed a high value of total phenolics and flavonoids. The nanoemulsion containing the encapsulated extract showed values of zeta potential, diameter and polydispersion index compatible with colloidal stability.
Conclusions: The nanoemulgel showed antioxidant and photoprotective activity with an SPF of 2.3 ± 0.1 and thermoresponsive with a sol-gel transition temperature of 23-24 °C, showing promise as a new cosmetic photoprotector that may contain a lower concentration of synthetic actives due to its SPF complementation attributed to Hymenaea courbaril stem extract.
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