NANOEMULSIONS BASED ON LINSEED OIL CONTAINING ENCAPSULATED ETHYL BUTYLACETYLAMINOPROPIONATE FOR REPELLENT APPLICATION
Abstract
Introduction: Mosquito-borne diseases are a global problem that causes deaths every year. Using synthetic repellents as a form of protection against diseases caused by mosquitoes can pose a risk to both the environment and human health due to their toxicity and low biodegradability. The present work aims to develop nanoemulsion formulations for the co-encapsulation of clove essential oil and ethyl butylacetylaminopropionate (IR3535®).
Methods: The formulations were prepared by the high energy method, thermodynamic stability tests of the nanoemulsions were carried out, the most stable formulation was characterized in terms of diameter, zeta potential, polydispersity index, encapsulation efficiency, morphology and rheology.
Results: The most stable nanoemulsion had a diameter of 188 ± 2 nm, -39 ± 1 mV zeta potential and 0.118–1.120 polydispersity index. The encapsulation efficiency was 61.33 ± 0.84%. In terms of morphology, the nanodroplets were spherical and without aggregates, typical of stable nanoemulsions. The rheological study identified the formulation as a pseudoplastic non-Newtonian fluid.
Conclusion: Therefore, the nanoemulsion containing clove essential oil and ethyl butylacetylaminopropionate was successfully obtained with stability characteristics, being promising as a topical nanorepellent with smaller amounts of synthetic active ingredient.
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