IN-VITRO EVALUATION OF ANTIOXIDATIVE, ANTIBACTERIAL, AND HEPATOPROTECTIVE EFFECT OF SMILAX ZEYLANICA L. AND BERBERIS ARISTATA DC
Antioxidant, Antibacterial & Hepatoprotective Potential of S. zeylanica and B. aristata
Abstract
Abstract
Background: The research examined the antioxidant, antibacterial, and hepatoprotective properties of hydroalcoholic extracts derived from Smilax zeylanica L. and Berberis aristata DC. Alkaloids, tannins, flavonoids, and glycosides were the major phytoconstituents, with a significant quantity of alkaloids and flavanones.
Objective: The hydroalcoholic extract of Smilax zeylanica exhibited an IC50 value of 6.29 μg/ml, while Berberis aristata demonstrated an IC50 value of 9.26 μg/ml in the DPPH (1,1-diphenyl-2- picrylhydrazyl) assay for antioxidant activity.
Methods: The modified extract showed significant antibacterial activity and Enterococcus faecalis exhibited significant susceptibility to the extract by using the disc diffusion method.
Results: The hepatoprotective activity of the extracts was assessed against HepG2 cells, and the extracts showed varying levels of hepatoprotection and cytotoxicity. Berberis aristata showed the highest hepatoprotective activity (IC50 < 47.09) among all the extracts.
Conclusion: From the above, it is suggested that natural antioxidants, antibacterials, and hepatoprotective properties of plant extracts of Smilax zeylanica and Berberis aristata could be promising for further research and can be used to develop effective antibacterial agents against microbial infections.
Downloads
All the articles published in JAPSR are distributed under a creative commons license (CC BY-NC-SA 4.0)
Under this license, you are free to:
- Share- copy and redistribute the material in any medium or format for any purpose, even commercially.
- Adapt- remix, transform, and build upon the material for any purpose, even commercially.
The licensor cannot revoke these freedoms as long as you follow the license terms.
- Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes .
- ShareAlike — If you remix, transform, or build upon the material, you must distribute your contributions under the same license as the original.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Copyright policy
The journal allows the author(s) to hold the copyright of their work. That means the authors do not need to transfer the copyright of their work to the journal. However, the authors grant JAPSR a license to publish the article and identify itself as the original publisher.
Licensing policy
The journal allows the author(s) to hold the copyright of their work. That means the authors do not need to transfer the copyright of their work to the journal. However, the authors grant JAPSR a license to publish the article and identify itself as the original publisher.