COMPREHENSIVE INSIGHTS INTO GASTRIC ULCER THERAPIES: A REVIEW OF CURRENT APPROACHES
Abstract
Gastric ulcers represent a significant healthcare burden globally, necessitating comprehensive management strategies to optimize patient outcomes. This review provides an overview of current treatments for gastric ulcers, covering pharmacological and non-pharmacological interventions, novel therapeutic approaches, and future directions for research and innovation. The introduction outlines the epidemiology, etiology, and pathophysiology of gastric ulcers, highlighting the complex interplay of genetic, environmental, and lifestyle factors. Clinical presentation and complications are discussed, emphasizing the need for effective management strategies. Pharmacological treatments, including proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2RAs), mucosal protective agents, anti-inflammatory agents, and antibiotic therapy for Helicobacter pylori eradication, are reviewed in detail. Non-pharmacological interventions such as lifestyle modifications, endoscopic interventions, and surgical options offer complementary approaches to ulcer management. Novel therapeutic approaches, including emerging pharmacological agents, innovative endoscopic techniques, and integrative medicine approaches, hold promise for advancing ulcer treatment. Comparative effectiveness and safety analyses provide insights into treatment selection and individualized approaches. Challenges such as antibiotic resistance and adverse effects of pharmacological therapies underscore the need for continued research and innovation. Opportunities for personalized medicine and precision therapies offer potential for improving treatment outcomes and reducing the burden of gastric ulcers worldwide. In conclusion, a multidimensional approach integrating pharmacological and non-pharmacological interventions is essential for effective gastric ulcer management. Future research should focus on addressing current challenges and advancing personalized therapeutic approaches to optimize patient care and outcomes.
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