TREATMENT OF HELICOBACTER PYLORI INFECTION: A REVIEW

  • Haidari Said Rahatullah Rokhan Institute of Higher Education, Medical Faculty, Jalalabad City, Nangarhar, Afghanistan

Abstract

 Helicobacter pylori is a particular bacterium that has evolved to survive in the acidic environment of the human stomach. Currently, no single antibiotic can treat the infection, so multiple medications are needed for treatment. Two antibiotics given more than a few times each day for seven to fourteen days, together with acid-suppressing medications, are the standard recommended treatments. The purpose of this review was to conclude the treatment of H.pylori infection. Without standard triple therapy, which consists of amoxicillin, clarithromycin, and PPI for the first five days, followed by PPI, clarithromycin, and tinidazole for the final five days, is the most frequently used course of treatment for clarithromycin-resistant H. pylori infections. Moreover, One of the first therapeutic regimens for the removal of H. pylori infection included bismuth-based therapy (bismuth salts, metronidazole, and tetracycline, each four times daily for two weeks with PPI), but the number of tablets taken daily and the associated mild side effects can have a negative effect on tolerance and compliance. Therefore, it is usually kept as a second-line treatment. Finally, rescue therapy (PPIs, Levofloxacin, and amoxicillin twice daily for 10 days) is a recently suggested treatment for H. pylori infection. This combination can cure about 80% of patients with H. pylori infection who have already tried one or more earlier treatments but failed.


 

Keywords: Helicobacter pylori, Infection, Treatment

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How to Cite
Rahatullah, H. “TREATMENT OF HELICOBACTER PYLORI INFECTION: A REVIEW”. Journal of Applied Pharmaceutical Sciences and Research, Vol. 6, no. 4, Feb. 2024, pp. 1-5, doi:10.31069/japsr.v6i4.01.
Section
Review Articles