OPTIMIZATION AND CHARACTERIZATION OF MELOXICAM ORODISPERSIBLE TABLETS USING MIXED HYDROTROPY FOR ENHANCED WATER SOLUBILITY

Meloxicam solubility enhancement with mixed hydrotrophy

  • Shikha Shukla Assistant Professor, Ram-Eesh Institute of Vocational and Technical Education, Greater Noida ; Research Scholar, School of Pharmaceutical Sciences, Sharda Univerity, Greater Noida, Uttar Pradesh, India
  • Vivek Chauhan Professor, Metro College of Health Sciences and Research, Greater Noida, Uttar Pradesh, India
  • Rahul Kaushik Professor, Metro College of Health Sciences and Research, Greater Noida, Uttar Pradesh, India

Abstract

Introduction: In order to attain rapid discharge in saliva and enhanced absorption, drug was incorporated in a fast-dissolving dosage form (ODTs) as a solid dispersion.  In this present work ODTs of Meloxicam were prepared by sublimation techniques where different subliming agents were used with super disintegrant. Materials and Methods: Hydrotropic solid dispersions were prepared using different ratios (1:2, 1:4 and 1:6) of drug and hydrotropic blends (Niacinamide, Anhy. Sodium citrate, Sodium Salicylate and Sodium benzoate). Best hydrotropic solid dispersion was selected to prepare ODTs comprising of croscarmellose sodium and camphor in different concentration along with other pharmaceutical excipients. From the primary trial batches, T3 was selected for optimization experimental designs due to lowest disintegration time and highest in vitro drug release. Secondary batches (F1-F9) were prepared by using 32 full factorial design with different concentration of croscarmellose sodium (12, 14 and 16 mg) and camphor (8, 10 and 12 mg) as two independent variables while disintegration time and percent friability were considered as two dependent response variables. These formulations were subjected to study of various post compression evaluation parameters like hardness, thickness, friability, weight variation, disintegration time (25-117 sec) and in-vitro drug release (99.09%).


Result and Discussion: Equilibrium solubility studies were reported that by utilizing hydrotropy, the solubility of Meloxicam got enhanced from 20.5 to 140.96 times as compared to its aqueous solubility. The desirability fraction was used to optimize the response variables for specific targets, i.e., minimum disintegration time and maximum dissolution, and the responses obtained were consistent for experimental values.

Keywords: Factorial design, Meloxicam, Mixed hydrotropic solid dispersion, Orodispersible tablet, Solubility, Sublimation

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How to Cite
Shukla, S., V. Chauhan, and R. Kaushik. “OPTIMIZATION AND CHARACTERIZATION OF MELOXICAM ORODISPERSIBLE TABLETS USING MIXED HYDROTROPY FOR ENHANCED WATER SOLUBILITY”. Journal of Applied Pharmaceutical Sciences and Research, Vol. 6, no. 1, June 2023, pp. 41-49, doi:10.31069/japsr.v6i1.06.
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Research Articles