DEVELOPMENT OF GASTRORETENTIVE MUCOADHESIVE SOLID DOSAGES FORM CONTAINING AMOXICILLIN TRIHYDRATE AND RANITIDINE HCL FOR THE TREATMENT OF HELICOBACTER PYLORI INFECTIONS

H. pylori infection treatment approaches

  • Sushmita Mishra Sunder Deep Pharmacy College, Delhi-Hapur Expressway, NH-9(24), Dasna, Ghaziabad, Uttar Pradesh 201015
  • Shalini Sharma Sunder Deep Pharmacy College, Delhi-Hapur Expressway, NH-9(24), Dasna, Ghaziabad, Uttar Pradesh 201015
  • Sandeep Sahu Vedica College of B.Pharmacy, Ram Krishna Dharmarth Foundation University, Bhopal, M.P. 462033
  • Amrita Chourasia Rajiv Gandhi College of Pharmacy, Bhopal, M.P. Salliya, India, 462042

Abstract

Mucoadhesion can be explored in the design of drug delivery system. Mucoadhesive drug delivery systems interact with the mucus layer covering the mucosal epithelial surface, and mucin molecules, thus increasing the residence time of the dosage form at the site of absorption. The drugs having local action or possessing maximum absorption in gastrointestinal tract (GIT) requires increased duration of stay in GIT. Gastroretentive Mucoadhesive solid dosages form containing Amoxicillin Trihydrate and Ranitidine HCL were formulated to prolong the residence time of the dosage form at the site of application or absorption, and it results in intimate contact of the dosage form with the underline absorption surface. This combination is approved by FDA for the treatment of Helicobacter Pylori Infections. The formulation results in efficient absorption, enhanced bioavailability of the drugs due to a high surface to volume ratio and an improved therapeutic performance of the drug. The prolonged release of drug resulted in reduced frequency of drug administration and improved patient compliance. The optimized formulation was evaluated for various parameters i.e. hardness, friability, thickness, weight variation, drug content, dissolution study and swelling index.

Keywords: Gastric Retention Formulations (GRFs), Mucoadhesive, Amoxicillin Trihydrate, Ranitidine HCL, Helicobacter pylori (H. pylori)

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How to Cite
Mishra, S., S. Sharma, S. Sahu, and A. Chourasia. “DEVELOPMENT OF GASTRORETENTIVE MUCOADHESIVE SOLID DOSAGES FORM CONTAINING AMOXICILLIN TRIHYDRATE AND RANITIDINE HCL FOR THE TREATMENT OF HELICOBACTER PYLORI INFECTIONS”. Journal of Applied Pharmaceutical Sciences and Research, Vol. 6, no. 1, June 2023, pp. 34-40, doi:10.31069/japsr.v6i1.05.
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Research Articles