APPLICATION OF CURCUMINOIDS-LOADED NANOEMULSION FOR CANCER THERAPY

  • Ethanielda de Lima Coelho Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Fortaleza - CE, Brazil
  • Francisco Célio Feitosa de França Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Fortaleza - CE, Brazil
  • Louhana Moreira Rebouças Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Fortaleza - CE, Brazil
  • Antônia Flávia Justino Uchoa Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Fortaleza - CE, Brazil
  • Luana de Morais Semião Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Fortaleza - CE, Brazil
  • Deyse de Sousa Maia Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Fortaleza - CE, Brazil
  • Denise Ramos Moreira Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Fortaleza - CE, Brazil
  • Daniel Pascoalino Pinheiro Laboratory of Experimental Oncology, Center for Research and Drug Development, Federal University of Ceará, Fortaleza – CE, Brazil
  • Larissa Morais Ribeiro da Silva Department of Food Engineering, Federal University of Ceará, Fortaleza – CE, Brazil
  • Cláudia do Ó Pessoa Laboratory of Experimental Oncology, Center for Research and Drug Development, Federal University of Ceará, Fortaleza – CE, Brazil
  • Maria Elenir Nobre Pinho Ribeiro Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Fortaleza - CE, Brazil
  • Nágila Maria Pontes Silva Ricardo Laboratory of Polymers and Materials Innovation, Department of Organic and Inorganic Chemistry, Sciences Center, Federal University of Ceará, Campus of Pici, Fortaleza - CE, Brazil
DOI https://doi.org/10.31069/japsrv5i3.04

Abstract

INTRODUCTION: Curcuminoids and Oleic acid, reported in the literature as antioxidant and antitumor agents, were combined in nanoemulsion, using Pluronic F127 as a stabilizer.


METHODS: The main objective is to investigate its cytotoxic activity against cancer cells.


RESULTS AND DISCUSSION: The nanoemulsion show values of the particle size (251.4 ± 4.6 nm), zeta potential (-34.8 ± 1.0 mV), and pH (4.8) classifying it as stable and non-irritating for pharmacological applications. The main results indicate that, in the toxicity test in fish (Zebrafish), the nanoformulation proved to be biosafe and the evaluation of the antioxidant action (by DPPH) showed excellent antioxidant activity. Furthermore, in the vitro cytotoxicity studies, the nanoemulsions showed good cytotoxic activity, ideal for fighting Colorectal, Glioblastoma, and Leukemia cancers and more effectively in Prostate cancer. 

Keywords: Nanoemulsion, Curcuminoids, Oleic acid, Anticancer activity, Prostrate cancer

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How to Cite
Coelho, E., F. de França, L. Moreira Rebouças, A. Uchoa, L. Semião, D. Maia, D. Moreira, D. Pinheiro, L. da Silva, C. Pessoa, M. E. Ribeiro, and N. Ricardo. “APPLICATION OF CURCUMINOIDS-LOADED NANOEMULSION FOR CANCER THERAPY”. Journal of Applied Pharmaceutical Sciences and Research, Vol. 5, no. 3, Dec. 2022, pp. 34-39, doi:10.31069/japsrv5i3.04.
Issue
Vol 5 No 3 (2022): Volume 5, Issue 3, 2022
Section
Research Articles

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