USE OF TAFENOQUINE IN ANTIMALARIAL TREATMENT: A LITERATURE REVIEW

  • Cristiane Tefé-Silva Barão de Mauá University Centre
  • Nathália Del Vecchio França Barbosa Barão de Mauá, University Centre- Ribeirão Preto- SP, Brazil
  • Ana Júlia Fernandes Barão de Mauá, University Centre- Ribeirão Preto- SP, Brazil
  • Anne Kareninne Domingos de Matos Barão de Mauá, University Centre- Ribeirão Preto- SP, Brazil
  • Giulia Eugenio Oliveira Barão de Mauá, University Centre- Ribeirão Preto- SP, Brazil
  • Isabela Buck Miele Barão de Mauá, University Centre- Ribeirão Preto- SP, Brazil
  • Isabella Monteneri Benassi Melo Barão de Mauá, University Centre- Ribeirão Preto- SP, Brazil
  • Marcela Toledo Bortoletto Barão de Mauá, University Centre- Ribeirão Preto- SP, Brazil
  • Maria Laura Correa Aneli Barão de Mauá, University Centre- Ribeirão Preto- SP, Brazil
  • Yasmin Carolina Pereira Barão de Mauá, University Centre- Ribeirão Preto- SP, Brazil

Abstract

Besides the intensification of control measures, Plasmodium vivax poses a major challenge for malaria elimination efforts. This type of malaria parasite causes a persistent liver stage where the liver suffers the action of the hypnozoites, a form of the P. vivax that is very relevant at this stage of the infection and causes relapse of the disease and continued transmission. This literature review discusses an innovative treatment for malaria with tafenoquine (TQ), an 8-aminoquinoline synthetic primaquine analog that has been used in one dose for malaria relapse prevention and for prophylaxis due to its longer half-life, and its effects on the human body. Besides the use of tafenoquine, it was also necessary to discuss the Glucose-6-phosphate dehydrogenase (G6PD) deficiency, and the interaction of this enzyme with the 8-aminoquinolines, since both drugs may induce hemolytic anemia in patients with G6PD deficiency; therefore, the test to this deficiency is necessary before putting those patients under treatment with these drugs. The use of other drugs combined with tafenoquine was also reported. The drugs Primaquine, chloroquine, and other analogs, such as artemisinin and hybrids, were discussed in this article, along with their combined use and their greater or lesser help in the treatment.

Keywords: Malaria, Tafenoquine, Treatment

Downloads

Download data is not yet available.
Statistics
92 Views | 115 Downloads
How to Cite
Tefé-Silva, C., N. D. V. França Barbosa, A. J. Fernandes, A. K. Domingos de Matos, G. Eugenio Oliveira, I. Buck Miele, I. M. Benassi Melo, M. Toledo Bortoletto, M. Laura Correa Aneli, and Y. Carolina Pereira. “USE OF TAFENOQUINE IN ANTIMALARIAL TREATMENT: A LITERATURE REVIEW”. Journal of Applied Pharmaceutical Sciences and Research, Vol. 5, no. 1, June 2022, pp. 1-8, doi:10.31069/japsr.v5i1.1.
Section
Review Articles