PLANT-MEDIATED GREEN SYNTHESIS OF GOLD NANOPARTICLES AND THEIR ANTICANCER APPLICATIONS: AN UPDATED REVIEW
A Review on Anticancer Activity of Plant-mediated Gold Nanoparticles
Abstract
Due to the wide range of applications in the field of medicine, gold nanoparticles are the most promising agents in nanotechnology with a variety of physical, chemical, optical and mechanical properties. Researchers have been interested in the green synthesis of gold nanoparticles in recent years because of their wide range of applications and low toxicity. The synthesis of gold nanoparticles using plant-mediated extracts has shown the fastest reduction due to the presence of phytoconstituents like phenolic compounds, flavonoids, alkaloids, terpenoids, polyphenols, polysaccharides, etc. Proteins, vitamins and minerals are included in the extracts and act as stabilizing and capping agents. Gold nanoparticles are made from plant extracts and are of natural origin, they are thought to be safer for biomedical uses. In this review, we elaborate about the plant mediated biosynthesis of gold nanoparticles and its biological applications with special emphasize to cancer therapeutics.
Keywords:
Nanotechnology, Gold Nanoparticles, Green Synthesis, Plant Extracts, Anticancer Activity
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References
1. Hosny M, Fawzy M. Instantaneous phytosynthesis of gold nanoparticles via Persicaria salicifolia leaf extract and their medical applications. Adv Powder Technol. 2021;32(8):2891-2904. https://doi.org/10.1016/j.apt.2021.06.004.
2. Zhang N, Yu J, Liu P, Chang J, Ali D, Tian X. Gold nanoparticles synthesized from Curcuma wenyujin inhibits HER-2/neu transcription in breast cancer cells (MDA-MB-231/HER2). Arab J Chem. 2020;13(10):7264-7273. https://doi.org/10.1016/j.arabjc.2020.08.007.
3. Khandanlou R, Murthy V, Wang H. Gold nanoparticle-assisted enhancement in bioactive properties of Australian native plant extracts, Tasmannia lanceolata and Backhousia citriodora. Mater Sci Eng C. 2020;112:110922. https://doi.org/10.1016/j.msec.2020.110922.
4. Ismail EH, Saqer AMA, Assirey E, Naqvi A, Okasha RM. Successful Green Synthesis of Gold Nanoparticles using a Corchorus olitorius Extract and Their Antiproliferative Effect in Cancer Cells. Int J Mol Sci. 2018; 19(9):2612. https://doi.org/10.3390/ijms19092612.
5. Al-Radadi NS. Green Biosynthesis of Flaxseed Gold Nanoparticles (Au-NPs) as Potent Anti-cancer Agent Against Breast Cancer Cells. J Saudi Chem Soc. 2021;25(6):101243. https://doi.org/10.1016/j.jscs.2021.101243.
6. Lee KX, Shameli K, Yew YP, Teow SY, Jahangirian H, Rafiee-Moghaddam R, Webster TJ. Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications. Int J Nanomedicine. 2020;15:275-300. https://doi.org/10.2147/IJN.S233789.
7. Park JS, Ahn EY, Park Y. Asymmetric dumbbell-shaped silver nanoparticles and spherical gold nanoparticles green-synthesized by mangosteen (Garcinia mangostana) pericarp waste extracts. Int J Nanomedicine. 2017;12:6895-6908. https://doi.org/10.2147/IJN.S140190.
8. Wang D, Markus J, Wang C, Kim YJ, Mathiyalagan R, Aceituno VC, Ahn S, Yang DC. Green synthesis of gold and silver nanoparticles using aqueous extract of Cibotium barometz root. Artif Cells Nanomed Biotechnol. 2016;45(8):1548-1555. https://dx.doi.org/10.1080/21691401.2016.1260580.
9. Abd El-Moaty HI, Soliman NA, Hamad RS, Ismail EH, Sabry DY, Khalil MMH. Comparative therapeutic effects of Pituranthos tortuosus aqueous extract and phyto-synthesized gold nanoparticles on Helicobacter pylori, diabetic and cancer proliferation. S Afr J Bot. 2021;139:167-174. https://doi.org/10.1016/j.sajb.2021.02.009.
10. Zhang P, Wang P, Yan L, Liu L. Synthesis of gold nanoparticles with Solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells. Int J Nanomedicine. 2018;13:7047-7059. https://doi.org/10.2147/IJN.S180138.
11. Dhandapani S, Xu X, Wang R, Puja AM, Kim H, Perumalsamy H, Balusamy SR, Kim YJ. Biosynthesis of gold nanoparticles using Nigella sativa and Curtobacterium proimmune K3 and evaluation of their anticancer activity. Mater Sci Eng C Mater Biol Appl. 2021;127:112214. https://doi.org/10.1016/j.msec.2021.112214.
12. Kyzioł A, Łukasiewicz S, Sebastian V, Kuśtrowski P, Kozieł M, Majda D, Cierniak A. Towards plant-mediated chemistry - Au nanoparticles obtained using aqueous extract of Rosa damascena and their biological activity in vitro. J Inorg Biochem. 2021;214:111300. https://doi.org/10.1016/j.jinorgbio.2020.111300.
13. Siddiq MA, Thangam R, Madhan B, Alam MDS. Green (gemini) surfactant mediated gold nanoparticles green synthesis: Effect on triple negative breast cancer cells. Nano-Struct Nano-Objects. 2019;1:100373. https://doi.org/10.1016/j.nanoso.2019.100373.
14. Al-Radadi NS. Facile one-step green synthesis of gold nanoparticles (AuNp) using licorice root extract: Antimicrobial and anticancer study against HepG2 cell line. Arab J Chem. 2021;14(2):102956. https://doi.org/10.1016/j.arabjc.2020.102956.
15. Perveen K, Husain FM, Qais FA, et al. Microwave-Assisted Rapid Green Synthesis of Gold Nanoparticles Using Seed Extract of Trachyspermum ammi: ROS Mediated Biofilm Inhibition and Anticancer Activity. Biomolecules. 2021;11(2):197. https://doi.org/10.3390/biom11020197.
16. Kumar B, Smita K, Cumbal L, Camacho J, Hernández-Gallegos E, de Guadalupe Chávez-López M, Grijalva M, Andrade K. One pot phytosynthesis of gold nanoparticles using Genipa americana fruit extract and its biological applications. Mater Sci Eng C Mater Biol Appl. 2016;62:725-31. https://doi.org/10.1016/j.msec.2016.02.029.
17. Vijayan R, Joseph S, Mathew B. Indigofera tinctoria leaf extract mediated green synthesis of silver and gold nanoparticles and assessment of their anticancer, antimicrobial, antioxidant and catalytic properties. Artif Cells Nanomed Biotechnol. 2018;46(4):861-871. https://doi.org/10.1080/21691401.2017.1345930.
18. Nirmala JG, Rachineni K, Choudhary S, Hosur RV, Lopus M. Triphala polyphenols-functionalized gold nanoparticles impair cancer cell survival through induction of tubulin dysfunction. J Drug Deliv Sci Technol. 2021;61:102167. https://doi.org/10.1016/j.jddst.2020.102167.
19. Adewale OB, Anadozie SO, Potts-Johnson SS, Onwuelu JO, Obafemi TO, Osukoya OA, Fadaka AO, Davids H, Roux S. Investigation of bioactive compounds in Crassocephalum rubens leaf and in vitro anticancer activity of its biosynthesized gold nanoparticles. Biotechnol Rep. 2020;28:e00560. https://doi.org/10.1016/j.btre.2020.e00560.
20. Valsalam S, Agastian P, Esmail GA, Ghilan AKM, Al-Dhabi NA, Arasu MV. Biosynthesis of silver and gold nanoparticles using Musa acuminata colla flower and its pharmaceutical activity against bacteria and anticancer efficacy. J Photochem Photobiol B: Biol. 2019;201:111670. https://doi.org/10.1016/j.jphotobiol.2019.111670.
21. Vijayakumar S. Eco-friendly synthesis of gold nanoparticles using fruit extracts and in vitro anticancer studies. J Saudi Chem Soc. 2019;23(6):753-761. https://doi.org/10.1016/j.jscs.2018.12.002.
22. Izadiyan Z, Shameli K, Hara H, Taib SHM. Cytotoxicity assay of biosynthesis gold nanoparticles mediated by walnut (Juglans regia) green husk extract. J Mol Struct. 2018;151:97-105. https://doi.org/10.1016/j.molstruc.2017.09.039.
23. Oueslati MH, Tahar LB, Harrath AH. Catalytic, antioxidant and anticancer activities of gold nanoparticles synthesized by kaempferol glucoside from Lotus Leguminosae. Arab J Chem. 2020;13(1):3112-3122. https://doi.org/10.1016/j.arabjc.2018.09.003.
24. Hamelian M, Hemmati S, Varmira K, Veisi H. Green synthesis, antibacterial, antioxidant and cytotoxic effect of gold nanoparticles using Pistacia Atlantica extract. J Taiwan Inst Chem Eng. 2018;93:21-30. https://doi.org/10.1016/j.jtice.2018.07.018.
25. Rajeshkumar S, Sherif MH, Malarkodi C, Ponnanikajamideen M, Arasu MV, Al-Dhabi NA, Roopan SM. Cytotoxicity behaviour of response surface model optimized gold nanoparticles by utilizing fucoidan extracted from padina tetrastromatica. J Mol Struct. 2021;1228:129440. https://doi.org/10.1016/j.molstruc.2020.129440.
26. Dorosti N, Jamshidi F. Plant-mediated gold nanoparticles by Dracocephalum kotschyi as anticholinesterase agent: Synthesis, characterization and evaluation of anticancer and antibacterial activity. J Appl Biomed. 2016;14(3):235-245. https://doi.org/10.1016/j.jab.2016.03.001.
27. Pandiyan N, Murugesan B, Arumugam M, Chinnaalagu D, Samayanan S, Mahalingam S. Ionic liquid mediated green synthesis of Ag-Au/Y2O3 nanoparticles using leaves extracts of Justicia adhatoda: Structural characterization and its biological applications. Adv Powder Technol. 2021;32(7):2213-2225. https://doi.org/10.1016/j.apt.2021.04.030.
28. Liu Y, Kim S, Kim YJ, Perumalsamy H, Lee S, Hwang E, Yi TH. Green synthesis of gold nanoparticles using Euphrasia officinalisleaf extract to inhibit lipopolysaccharide-induced inflammation through NF-κB and JAK/STAT pathways in RAW 264.7 macrophages. Int J Nanomedicine. 2019;14:2945-2959. https://doi.org/10.2147/IJN.S199781.
29. Kumari P, Meena A. Green synthesis of gold nanoparticles from Lawsonia inermis and its catalytic activities following the Langmuir-Hinshelwood mechanism. Colloids Surf A: Physicochem Eng Asp. 2020;606:125447. https://doi.org/10.1016/j.colsurfa.2020.125447.
30. Uzma M, Sunayana N, Raghavendra VB, Madhu CS, Shanmuganathan R, Brindhadevi K. Biogenic synthesis of gold nanoparticles using Commiphora wightii and their cytotoxic effects on breast cancer cell line (MCF-7). Process Biochem. 2020;92:269-276. https://doi.org/10.1016/j.procbio.2020.01.019.
31. Jeyarani S, Vinita NM, Puja P, Senthamilselvi S, Devan U, Velangani AJ, Biruntha M, Pugazhendhi A, Kumar P. Biomimetic gold nanoparticles for its cytotoxicity and biocompatibility evidenced by fluorescence-based assays in cancer (MDA-MB-231) and non-cancerous (HEK-293) cells. J Photochem Photobiol B. 2020;202:111715. https://doi.org/10.1016/j.jphotobiol.2019.111715.
32. Nirmala JG, Akila S, Narendhirakannan RT, Chatterjee S. Vitis vinifera peel polyphenols stabilized gold nanoparticles induce cytotoxicity and apoptotic cell death in A431 skin cancer cell lines. Adv Powder Technol. 2017;28(4):1170-1184. https://doi.org/10.1016/j.apt.2017.02.003.
33. Blom van Staden A, Kovacs D, Cardinali G, Picardo M, Lebeko M, Khumalo NC, Ray SS, Lall N. Synthesis and characterization of gold nanoparticles biosynthesised from Aspalathus linearis (Burm.f.) R.Dahlgren For progressive macular hypomelanosis. J Herb Med. 2021;29:100481. https://doi.org/10.1016/j.hermed.2021.100481.
34. Vimalraj S, Ashokkumar T, Saravanan S. Biogenic gold nanoparticles synthesis mediated by Mangifera indica seed aqueous extracts exhibits antibacterial, anticancer and anti-angiogenic properties. Biomed Pharmacother. 2018;105:440-448. https://doi.org/10.1016/j.biopha.2018.05.151.
35. Huo Y, Singh P, Kim YJ, Soshnikova V, Kang J, Markus J, Ahn S, Castro-Aceituno V, Mathiyalagan R, Chokkalingam M, Bae K, Yang DC. Biological synthesis of gold and silver chloride nanoparticles by Glycyrrhiza uralensis and in vitro applications. Artif Cells Nanomed Biotechnol. 2018;46(2):303-312. https://doi.org/10.1080/21691401.2017.1307213.
36. El-Borady OM, Ayat MS, Shabrawy MA, Millet P. Green synthesis of gold nanoparticles using Parsley leaves extract and their applications as an alternative catalytic, antioxidant, anticancer and antibacterial agents. Adv Powder Technol. 2020;31(10):4390-4400. https://doi.org/10.1016/j.apt.2020.09.017.
37. Liu Q, Wu F, Chen Y, Alrashood ST, Alharbi SA. Anti-human colon cancer properties of a novel chemotherapeutic supplement formulated by gold nanoparticles containing Allium sativum L. leaf aqueous extract and investigation of its cytotoxicity and antioxidant activities. Arab J Chem. 2021;14(4):103039. https://doi.org/10.1016/j.arabjc.2021.103039.
38. Jiménez Pérez ZE, Mathiyalagan R, Markus J, Kim YJ, Kang HM, Abbai R, Seo KH, Wang D, Soshnikova V, Yang DC. Ginseng-berry-mediated gold and silver nanoparticle synthesis and evaluation of their in vitro antioxidant, antimicrobial and cytotoxicity effects on human dermal fibroblast and murine melanoma skin cell lines. Int J Nanomedicine. 2017;12:709-723. https://doi.org/10.2147/IJN.S118373.
39. Ke Y, Al Aboody MS, Alturaiki W, Alsagaby SA, Alfaiz FA, Veeraraghavan VP, Mickymaray S. Photosynthesized gold nanoparticles from Catharanthus roseus induces caspase-mediated apoptosis in cervical cancer cells (HeLa). Artif Cells Nanomed Biotechnol. 2019;47(1):1938-1946. https://doi.org/10.1080/21691401.2019.1614017.
40. Chen J, Li Y, Fang G, Cao Z, Shang Y, Alfarraj S, Alharbi SA, Li J, Yang S, Duan X. Green synthesis, characterization, cytotoxicity, antioxidant and anti-human ovarian cancer activities of Curcumae kwangsiensis leaf aqueous extract green-synthesized gold nanoparticles. Arab J Chem. 2021;14(3):103000. https://doi.org/10.1016/j.arabjc.2021.103000.
41. Reyes-Becerril M, Ruvalcaba F, Sanchez V, López MG, Silva-Jara J, Hernandez-Adame L, Angulo C. Green synthesis of gold nanoparticles using Turnera diffusa Willd enhanced antimicrobial properties and immune response in Longfin yellowtail leukocytes. Aquac Res. 2021;52:3391-3402. https://doi.org/10.1111/are.15184.
42. Li. S, Al-Misned FA, El-Serehy HA, Yang L. Green synthesis of gold nanoparticles using aqueous extract of Mentha Longifolia leaf and investigation of its anti-human breast carcinoma properties in the in vitro condition. Arab J Chem. 2021;14(2):102931. https://doi.org/10.1016/j.arabjc.2020.102931.
43. Rajan A, Rajan AR, Philip D. Elettaria cardamomum seed mediated rapid synthesis of gold nanoparticles and its biological activities. OpenNano. 2017;2:1-8. https://doi.org/10.1016/j.onano.2016.11.002.
44. Yun Z, Chinnathambi A, Alharbi SA, Jin Z. Biosynthesis of gold nanoparticles using Vetex negundo and evaluation of pro-apoptotic effect on human gastric cancer cell lines. J Photochem Photobiol B: Biol. 2020;203:111749. https://doi.org/10.1016/j.jphotobiol.2019.111749.
45. Umapathi A, Navya PN, Madhyastha H, Singh M, Madhyastha R, Maruyama M, Daima HK. Curcumin and isonicotinic acid hydrazide functionalized gold nanoparticles for selective anticancer action. Colloids Surf A: Physicochem Eng Asp. 2020;607:125484. https://doi.org/10.1016/j.colsurfa.2020.125484.
46. Hoshyar R, Khayati GR, Poorgholami M, Kaykhaii M. A novel green one-step synthesis of gold nanoparticles using crocin and their anti-cancer activities. J Photochem Photobiol B. 2016;159:237-42. https://doi.org/10.1016/j.jphotobiol.2016.03.056.
47. Singh N, Das MK, Ansari A, Mohanta D, Rajamani P. Biogenic nanosized gold particles: Physico-chemical characterization and its anticancer response against breast cancer. Biotechnol Rep. 2021;30:e00612. https://doi.org/10.1016/j.btre.2021.e00612.
48. Sharma B, Deswal R. Single pot synthesized gold nanoparticles using Hippophae rhamnoides leaf and berry extract showed shape-dependent differential nanobiotechnological applications. Artif Cells Nanomed Biotechnol. 2018;46(sup2):408-418. https://doi.org/10.1080/21691401.2018.1458034.
49. Pechyen C, Ponsanti K, Tangnorawich B, Ngernyuang N. Waste fruit peel – Mediated green synthesis of biocompatible gold nanoparticles. J Mater Res Technol. 2021;14:2982-2991. https://doi.org/10.1016/j.jmrt.2021.08.111.
50. Chang Y, Zheng C, Chinnathambi A, Alahmadi TA, Alharbi SA. Cytotoxicity, anti-acute leukemia and antioxidant properties of gold nanoparticles green-synthesized using Cannabis sativa L leaf aqueous extract. Arab J Chem. 2021;14(4):103060. https://doi.org/10.1016/j.arabjc.2021.103060.
51. Sunderam V, Thiyagarajan D, Lawrence AV, Mohammed SSS, Selvaraj A. In-vitro antimicrobial and anticancer properties of green synthesized gold nanoparticles using Anacardium occidentale leaves extract. Saudi J Biol Sci. 2019;26(3):455-459. https://doi.org/10.1016/j.sjbs.2018.12.001.
52. Zhang X, Tan Z, Jia K, Zhang W, Dang M. Rabdosia rubescens Linn: green synthesis of gold nanoparticles and their anticancer effects against human lung cancer cells A549. Artif Cells Nanomed Biotechnol. 2019;47(1):2171-2178. https://doi.org/10.1080/21691401.2019.1620249.
53. Park SY, Kim B, Cui Z, Park G, Choi YW. Anti-Metastatic Effect of Gold Nanoparticle-Conjugated Maclura tricuspidata Extract on Human Hepatocellular Carcinoma Cells. Int J Nanomedicine. 2020;15:5317-5331. https://doi.org/10.2147/IJN.S246724.
54. Seetharaman P, Chandrasekaran R, Gnanasekar S, Mani I, Sivaperumal S. Biogenic gold nanoparticles synthesized using Crescentia cujete L. and evaluation of their different biological activities. Biocatal Agric Biotechnol. 2017;11:75-82. https://doi.org/10.1016/j.bcab.2017.06.004.
55. Imran M, Husseini G, Awad N, Paul V, El-Haj BM, Ali HS. An Effective Anticancer Nano-approach for Melanoma and Breast Cancers Using Annona muricata Gold Nanoparticles. Acta Sci Pharm Sci. 2021;5(9):46-54. https://doi.org/10.31080/ASPS.2021.05.0782.
56. Vemuri SK, Banala RR, Mukherjee S, Uppula P, Gpv S, A V GR, T M. Novel biosynthesized gold nanoparticles as anti-cancer agents against breast cancer: Synthesis, biological evaluation, molecular modelling studies. Mater Sci Eng C Mater Biol Appl. 2019;99:417-429. https://doi.org/10.1016/j.msec.2019.01.123.
57. Chahardoli A, Karimi N, Fattahi A, Salimikia I. Biological applications of phytosynthesized gold nanoparticles using leaf extract of Dracocephalum kotschyi. J Biomed Mater Res A. 2019;107(3):621-630. https://doi.org/10.1002/jbm.a.36578.
58. Nagalingam M, Kalpana VN, Rajeswari VD, Panneerselvam A. Biosynthesis, characterization and evaluation of bioactivities of leaf extract-mediated biocompatible gold nanoparticles from Alternanthera bettzickiana. Biotechnol Rep. 2018;19:e00268. https://doi.org/10.1016/j.btre.2018.e00268.
59. Patil MP, Bayaraa E, Subedi P, Piad LLA, Tarte NH, Kim GD. Biogenic synthesis, characterization of gold nanoparticles using Lonicera japonica and their anticancer activity on HeLa cells. J Drug Deliv Sci Technol. 2019;51:83-90. https://doi.org/10.1016/j.jddst.2019.02.021.
60. Dhayalan M, Denison MIJ, Ayyar M, Gandhi NN, Krishnan K, Abdulhadi B. Biogenic synthesis, characterization of gold and silver nanoparticles from Coleus forskohlii and their clinical importance. J Photochem Photobiol B: Biol. 2018;183:251-257. https://doi.org/10.1016/j.jphotobiol.2018.04.042.
61. Chokkalingam M, Singh P, Huo Y, Soshnikova V, Ahn S, Kang J, Mathiyalagan R, Kim YJ, Yang DC. Facile synthesis of Au and Ag nanoparticles using fruit extract of Lycium chinense and their anticancer activity. J Drug Deliv Sci Technol. 2019;49:308-315. https://doi.org/10.1016/j.jddst.2018.11.025.
62. Hamelian M, Varmira K, Veisi H. Green synthesis and characterizations of gold nanoparticles using Thyme and survey cytotoxic effect, antibacterial and antioxidant potential. J Photochem Photobiol B. 2018;184:71-79. https://doi.org/10.1016/j.jphotobiol.2018.05.016.
63. Boomi P, Ganesan RM, Poorani G, Gurumallesh Prabu H, Ravikumar S, Jeyakanthan J. Biological synergy of greener gold nanoparticles by using Coleus aromaticus leaf extract. Mater Sci Eng C Mater Biol Appl. 2019;99:202-210. https://doi.org/10.1016/j.msec.2019.01.105.
64. Kumar PS, Jeyalatha MV, Malathi J, Ignacimuthu S. Anticancer effects of one-pot synthesized biogenic gold nanoparticles (Mc-AuNps) against laryngeal carcinoma. J Drug Deliv Sci Technol. 2018;44:118-128. https://doi.org/10.1016/j.jddst.2017.12.008.
65. Balashanmugam P, Durai P, Balakumaran MD, Kalaichelvan PT. Phytosynthesized gold nanoparticles from C. roxburghii DC. leaf and their toxic effects on normal and cancer cell lines. J Photochem Photobiol B: Biol. 2016;165:163-173. https://doi.org/10.1016/j.jphotobiol.2016.10.013.
66. Balasubramanian S, Kala SMJ, Pushparaj TL. Biogenic synthesis of gold nanoparticles using Jasminum auriculatum leaf extract and their catalytic, antimicrobial and anticancer activities. J Drug Deliv Sci Technol. 2020;57:101620. https://doi.org/10.1016/j.jddst.2020.101620.
67. Godipurge SS, Yallappa S, Biradar NJ, Biradar JS, Dhananjaya BL, Hegde G, Jagadish K, Hegde G. A facile and green strategy for the synthesis of Au, Ag and Au–Ag alloy nanoparticles using aerial parts of R. hypocrateriformis extract and their biological evaluation. Enzyme Microb Technol. 2016;95:174-184. https://doi.org/10.1016/j.enzmictec.2016.08.006.
68. Vijayakumar S, Vaseeharan B, Malaikozhundan B, Gopi N, Ekambaram P, Pachaiappan R, Velusamy P, Murugan K, Benelli G, Suresh Kumar R, Suriyanarayanamoorthy M. Therapeutic effects of gold nanoparticles synthesized using Musa paradisiaca peel extract against multiple antibiotic resistant Enterococcus faecalis biofilms and human lung cancer cells (A549). Microb Pathog. 2017;102:173-183. https://doi.org/10.1016/j.micpath.2016.11.029.
69. Naraginti S, Li Y. Preliminary investigation of catalytic, antioxidant, anticancer and bactericidal activity of green synthesized silver and gold nanoparticles using Actinidia deliciosa. J Photochem Photobiol B: Biol. 2017;170:225-234. https://doi.org/10.1016/j.jphotobiol.2017.03.023.
70. Satpathy S, Patra A, Ahirwar B, Hussain MD. Process optimization for green synthesis of gold nanoparticles mediated by extract of Hygrophila spinosa T. Anders and their biological applications. Phys E: Low-dimens Syst Nanostructures. 2020;121:113830. https://doi.org/10.1016/j.physe.2019.113830.
71. Karthika V, Arumugam A, Gopinath K, Kaleeswarran P, Govindarajan M, Alharbi NS, Kadaikunnan S, Khaled JM, Benelli G. Guazuma ulmifolia bark-synthesized Ag, Au and Ag/Au alloy nanoparticles: Photocatalytic potential, DNA/protein interactions, anticancer activity and toxicity against 14 species of microbial pathogens. J Photochem Photobiol B: Biol. 2017;167:189-199. https://doi.org/10.1016/j.jphotobiol.2017.01.008.
72. Sun B, Hu N, Han L, Pi Y, Gao Y, Chen K. Anticancer activity of green synthesised gold nanoparticles from Marsdenia tenacissima inhibits A549 cell proliferation through the apoptotic pathway. Artif Cells Nanomed Biotechnol. 2019;47(1):4012-4019. https://doi.org/10.1080/21691401.2019.1575844.
73. Wang L, Xu J, Yan Y, Liu H, Li F. Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell lines. Artif Cells Nanomed Biotechnol. 2019;47(1):1216-1223. https://doi.org/10.1080/21691401.2019.1593852.
74. Patil MP, Jin X, Simeon NC, Palma J, Kim D, Ngabire D, Kim NH, Tarte NH, Kim GD. Anticancer activity of Sasa borealis leaf extract-mediated gold nanoparticles. Artif Cells Nanomed Biotechnol. 2017;46(1):82-88. https://doi.org/10.1080/21691401.2017.1293675.
75. Wu T, Duan X, Hu C, Wu C, Chen X, Huang J, Liu J, Cui S. Synthesis and characterization of gold nanoparticles from Abies spectabilis extract and its anticancer activity on bladder cancer T24 cells. Artif Cells Nanomed Biotechnol. 2019;47(1):512-523. https://doi.org/10.1080/21691401.2018.1560305.
76. Kuppusamy P, Ichwan SJA, Al-Zikri PNH, Suriyah WH Soundharrajan I, Govindan N, Maniam GP, Yusoff MM. In Vitro Anticancer Activity of Au, Ag Nanoparticles Synthesized Using Commelina nudiflora L. Aqueous Extract Against HCT-116 Colon Cancer Cells. Biol Trace Elem Res. 2016;173:297–305. https://doi.org/10.1007/s12011-016-0666-7.
77. Castro-Aceituno V, Abbai R, Moon SS, Ahn S, Mathiyalagan R, Kim YJ, Kim YJ, Yang DC. Pleuropterus multiflorus (Hasuo) mediated straightforward eco-friendly synthesis of silver, gold nanoparticles and evaluation of their anti-cancer activity on A549 lung cancer cell line. Biomed Pharmacother. 2017;93:995-1003. https://doi.org/10.1016/j.biopha.2017.07.040.
78. Divakaran D, Lakkakula JR, Thakur M, Kumawat MK, Srivastava R. Dragon fruit extract capped gold nanoparticles: Synthesis and their differential cytotoxicity effect on breast cancer cells. Mater Lett.2019;236:498-502. https://doi.org/10.1016/j.matlet.2018.10.156.
79. Wu F, Zhu J, Li G, Wang L, Veeraraghavan VP, Mohan SK, Zhang Q. Biologically synthesized green gold nanoparticles from Siberian ginseng induce growth-inhibitory effect on melanoma cells (B16). Artif Cells Nanomed Biotechnol. 2019;47(1):3297-3305, https://doi.org/10.1080/21691401.2019.1647224.
80. Elemike EE, Onwudiwe DC, Nundkumar N, Singh M, Iyekowa O. Green synthesis of Ag, Au and Ag-Au bimetallic nanoparticles using Stigmaphyllon ovatum leaf extract and their in vitro anticancer potential. Mater Lett. 2019;243:148-152. https://doi.org/10.1016/j.matlet.2019.02.049.
81. Barai AC, Paul K, Dey A, et al. Green synthesis of Nerium oleander-conjugated gold nanoparticles and study of its in vitro anticancer activity on MCF-7 cell lines and catalytic activity. Nano Converg. 2018;5(1):10. https://doi.org/10.1186/s40580-018-0142-5.
82. Zangeneh MM, Zangeneh A. Novel green synthesis of Hibiscus sabdariffa flower extract conjugated gold nanoparticles with excellent anti-acute myeloid leukemia effect in comparison to daunorubicin in a leukemic rodent model. Appl Organometal Chem. 2020;34:e5271. https://doi.org/10.1002/aoc.5271.
83. Wang L, Xu J, Yan Y, Liu H, Karunakaran T, Li F. Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1). Artif Cells Nanomed Biotechnol. 2019;47(1):1617-1627. https://doi.org/10.1080/21691401.2019.1594862.
84. Lee YJ, Ahn EY, Park Y. Shape-dependent cytotoxicity and cellular uptake of gold nanoparticles synthesized using green tea extract. Nanoscale Res Lett. 2019;14:129. https://doi.org/10.1186/s11671-019-2967-1.
85. Fanoro OT, Parani S, Maluleke R, Lebepe TC, Varghese JR, Mavumengwana V, Oluwafemi OS. Facile Green, Room-Temperature Synthesis of Gold Nanoparticles Using Combretum erythrophyllum Leaf Extract: Antibacterial and Cell Viability Studies against Normal and Cancerous Cells. Antibiotics.2021;10:893. https://doi.org/10.3390/antibiotics10080893.
86. Foo YY, Periasamy V, Kiew LV, Kumar GG, Malek SNA. Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity and Blood Compatibility. Nanomaterials. 2017; 7(6):123. https://doi.org/10.3390/nano7060123.
87. Tiloke C, Phulukdaree A, Anand K, Gengan RM, Chuturgoon AA. Moringa oleifera Gold Nanoparticles Modulate Oncogenes, Tumor Suppressor Genes and Caspase-9 Splice Variants in A549 Cells. J Cell Biochem. 2016;117:2302-2314. https://doi.org/10.1002/jcb.25528.
88. Mukundan D, Mohankumar R, Vasanthakumari R. Comparative study of synthesized silver and gold nanoparticles using leaves extract of Bauhinia tomentosa Linn and their anticancer efficacy. Bull Mater Sci. 2017;40:335–344. https://doi.org/10.1007/s12034-017-1376-2.
89. Rajakumar G, Gomathi T, Abdul Rahuman A, Thiruvengadam M, Mydhili G, Kim S-H, Lee T-J, Chung I-M. Biosynthesis and Biomedical Applications of Gold Nanoparticles Using Eclipta prostrata Leaf Extract. Appl Sci. 2016;6(8):222. https://doi.org/10.3390/app6080222.
90. Ghramh HA, Khan KA, Ibrahim EH, Setzer WN. Synthesis of Gold Nanoparticles (AuNPs) Using Ricinus communis Leaf Ethanol Extract, Their Characterization and Biological Applications. Nanomaterials. 2019;9(5):765. https://doi.org/10.3390/nano9050765.
91. Singh H, Du J, Singh P, Yi TH. Ecofriendly synthesis of silver and gold nanoparticles by Euphrasia officinalis leaf extract and its biomedical applications. Artif Cells Nanomed Biotechnol. 2017;46(6):1163-1170. https://doi.org/10.1080/21691401.2017.1362417.
92. Hemmati S, Joshani Z, Zangeneh A, Zangeneh MM. Green synthesis and chemical characterization of Thymus vulgaris leaf aqueous extract conjugated gold nanoparticles for the treatment of acute myeloid leukemia in comparison to doxorubicin in a leukemic mouse model. Appl Organometal Chem. 2020;34:e5267. https://doi.org/10.1002/aoc.5267.
93. Lee YJ, Song K, Cha S-H, Cho S, Kim YS, Park Y. Sesquiterpenoids from Tussilago farfara Flower Bud Extract for the Eco-Friendly Synthesis of Silver and Gold Nanoparticles Possessing Antibacterial and Anticancer Activities. Nanomaterials. 2019;9(6):819. https://doi.org/10.3390/nano9060819. .
2. Zhang N, Yu J, Liu P, Chang J, Ali D, Tian X. Gold nanoparticles synthesized from Curcuma wenyujin inhibits HER-2/neu transcription in breast cancer cells (MDA-MB-231/HER2). Arab J Chem. 2020;13(10):7264-7273. https://doi.org/10.1016/j.arabjc.2020.08.007.
3. Khandanlou R, Murthy V, Wang H. Gold nanoparticle-assisted enhancement in bioactive properties of Australian native plant extracts, Tasmannia lanceolata and Backhousia citriodora. Mater Sci Eng C. 2020;112:110922. https://doi.org/10.1016/j.msec.2020.110922.
4. Ismail EH, Saqer AMA, Assirey E, Naqvi A, Okasha RM. Successful Green Synthesis of Gold Nanoparticles using a Corchorus olitorius Extract and Their Antiproliferative Effect in Cancer Cells. Int J Mol Sci. 2018; 19(9):2612. https://doi.org/10.3390/ijms19092612.
5. Al-Radadi NS. Green Biosynthesis of Flaxseed Gold Nanoparticles (Au-NPs) as Potent Anti-cancer Agent Against Breast Cancer Cells. J Saudi Chem Soc. 2021;25(6):101243. https://doi.org/10.1016/j.jscs.2021.101243.
6. Lee KX, Shameli K, Yew YP, Teow SY, Jahangirian H, Rafiee-Moghaddam R, Webster TJ. Recent Developments in the Facile Bio-Synthesis of Gold Nanoparticles (AuNPs) and Their Biomedical Applications. Int J Nanomedicine. 2020;15:275-300. https://doi.org/10.2147/IJN.S233789.
7. Park JS, Ahn EY, Park Y. Asymmetric dumbbell-shaped silver nanoparticles and spherical gold nanoparticles green-synthesized by mangosteen (Garcinia mangostana) pericarp waste extracts. Int J Nanomedicine. 2017;12:6895-6908. https://doi.org/10.2147/IJN.S140190.
8. Wang D, Markus J, Wang C, Kim YJ, Mathiyalagan R, Aceituno VC, Ahn S, Yang DC. Green synthesis of gold and silver nanoparticles using aqueous extract of Cibotium barometz root. Artif Cells Nanomed Biotechnol. 2016;45(8):1548-1555. https://dx.doi.org/10.1080/21691401.2016.1260580.
9. Abd El-Moaty HI, Soliman NA, Hamad RS, Ismail EH, Sabry DY, Khalil MMH. Comparative therapeutic effects of Pituranthos tortuosus aqueous extract and phyto-synthesized gold nanoparticles on Helicobacter pylori, diabetic and cancer proliferation. S Afr J Bot. 2021;139:167-174. https://doi.org/10.1016/j.sajb.2021.02.009.
10. Zhang P, Wang P, Yan L, Liu L. Synthesis of gold nanoparticles with Solanum xanthocarpum extract and their in vitro anticancer potential on nasopharyngeal carcinoma cells. Int J Nanomedicine. 2018;13:7047-7059. https://doi.org/10.2147/IJN.S180138.
11. Dhandapani S, Xu X, Wang R, Puja AM, Kim H, Perumalsamy H, Balusamy SR, Kim YJ. Biosynthesis of gold nanoparticles using Nigella sativa and Curtobacterium proimmune K3 and evaluation of their anticancer activity. Mater Sci Eng C Mater Biol Appl. 2021;127:112214. https://doi.org/10.1016/j.msec.2021.112214.
12. Kyzioł A, Łukasiewicz S, Sebastian V, Kuśtrowski P, Kozieł M, Majda D, Cierniak A. Towards plant-mediated chemistry - Au nanoparticles obtained using aqueous extract of Rosa damascena and their biological activity in vitro. J Inorg Biochem. 2021;214:111300. https://doi.org/10.1016/j.jinorgbio.2020.111300.
13. Siddiq MA, Thangam R, Madhan B, Alam MDS. Green (gemini) surfactant mediated gold nanoparticles green synthesis: Effect on triple negative breast cancer cells. Nano-Struct Nano-Objects. 2019;1:100373. https://doi.org/10.1016/j.nanoso.2019.100373.
14. Al-Radadi NS. Facile one-step green synthesis of gold nanoparticles (AuNp) using licorice root extract: Antimicrobial and anticancer study against HepG2 cell line. Arab J Chem. 2021;14(2):102956. https://doi.org/10.1016/j.arabjc.2020.102956.
15. Perveen K, Husain FM, Qais FA, et al. Microwave-Assisted Rapid Green Synthesis of Gold Nanoparticles Using Seed Extract of Trachyspermum ammi: ROS Mediated Biofilm Inhibition and Anticancer Activity. Biomolecules. 2021;11(2):197. https://doi.org/10.3390/biom11020197.
16. Kumar B, Smita K, Cumbal L, Camacho J, Hernández-Gallegos E, de Guadalupe Chávez-López M, Grijalva M, Andrade K. One pot phytosynthesis of gold nanoparticles using Genipa americana fruit extract and its biological applications. Mater Sci Eng C Mater Biol Appl. 2016;62:725-31. https://doi.org/10.1016/j.msec.2016.02.029.
17. Vijayan R, Joseph S, Mathew B. Indigofera tinctoria leaf extract mediated green synthesis of silver and gold nanoparticles and assessment of their anticancer, antimicrobial, antioxidant and catalytic properties. Artif Cells Nanomed Biotechnol. 2018;46(4):861-871. https://doi.org/10.1080/21691401.2017.1345930.
18. Nirmala JG, Rachineni K, Choudhary S, Hosur RV, Lopus M. Triphala polyphenols-functionalized gold nanoparticles impair cancer cell survival through induction of tubulin dysfunction. J Drug Deliv Sci Technol. 2021;61:102167. https://doi.org/10.1016/j.jddst.2020.102167.
19. Adewale OB, Anadozie SO, Potts-Johnson SS, Onwuelu JO, Obafemi TO, Osukoya OA, Fadaka AO, Davids H, Roux S. Investigation of bioactive compounds in Crassocephalum rubens leaf and in vitro anticancer activity of its biosynthesized gold nanoparticles. Biotechnol Rep. 2020;28:e00560. https://doi.org/10.1016/j.btre.2020.e00560.
20. Valsalam S, Agastian P, Esmail GA, Ghilan AKM, Al-Dhabi NA, Arasu MV. Biosynthesis of silver and gold nanoparticles using Musa acuminata colla flower and its pharmaceutical activity against bacteria and anticancer efficacy. J Photochem Photobiol B: Biol. 2019;201:111670. https://doi.org/10.1016/j.jphotobiol.2019.111670.
21. Vijayakumar S. Eco-friendly synthesis of gold nanoparticles using fruit extracts and in vitro anticancer studies. J Saudi Chem Soc. 2019;23(6):753-761. https://doi.org/10.1016/j.jscs.2018.12.002.
22. Izadiyan Z, Shameli K, Hara H, Taib SHM. Cytotoxicity assay of biosynthesis gold nanoparticles mediated by walnut (Juglans regia) green husk extract. J Mol Struct. 2018;151:97-105. https://doi.org/10.1016/j.molstruc.2017.09.039.
23. Oueslati MH, Tahar LB, Harrath AH. Catalytic, antioxidant and anticancer activities of gold nanoparticles synthesized by kaempferol glucoside from Lotus Leguminosae. Arab J Chem. 2020;13(1):3112-3122. https://doi.org/10.1016/j.arabjc.2018.09.003.
24. Hamelian M, Hemmati S, Varmira K, Veisi H. Green synthesis, antibacterial, antioxidant and cytotoxic effect of gold nanoparticles using Pistacia Atlantica extract. J Taiwan Inst Chem Eng. 2018;93:21-30. https://doi.org/10.1016/j.jtice.2018.07.018.
25. Rajeshkumar S, Sherif MH, Malarkodi C, Ponnanikajamideen M, Arasu MV, Al-Dhabi NA, Roopan SM. Cytotoxicity behaviour of response surface model optimized gold nanoparticles by utilizing fucoidan extracted from padina tetrastromatica. J Mol Struct. 2021;1228:129440. https://doi.org/10.1016/j.molstruc.2020.129440.
26. Dorosti N, Jamshidi F. Plant-mediated gold nanoparticles by Dracocephalum kotschyi as anticholinesterase agent: Synthesis, characterization and evaluation of anticancer and antibacterial activity. J Appl Biomed. 2016;14(3):235-245. https://doi.org/10.1016/j.jab.2016.03.001.
27. Pandiyan N, Murugesan B, Arumugam M, Chinnaalagu D, Samayanan S, Mahalingam S. Ionic liquid mediated green synthesis of Ag-Au/Y2O3 nanoparticles using leaves extracts of Justicia adhatoda: Structural characterization and its biological applications. Adv Powder Technol. 2021;32(7):2213-2225. https://doi.org/10.1016/j.apt.2021.04.030.
28. Liu Y, Kim S, Kim YJ, Perumalsamy H, Lee S, Hwang E, Yi TH. Green synthesis of gold nanoparticles using Euphrasia officinalisleaf extract to inhibit lipopolysaccharide-induced inflammation through NF-κB and JAK/STAT pathways in RAW 264.7 macrophages. Int J Nanomedicine. 2019;14:2945-2959. https://doi.org/10.2147/IJN.S199781.
29. Kumari P, Meena A. Green synthesis of gold nanoparticles from Lawsonia inermis and its catalytic activities following the Langmuir-Hinshelwood mechanism. Colloids Surf A: Physicochem Eng Asp. 2020;606:125447. https://doi.org/10.1016/j.colsurfa.2020.125447.
30. Uzma M, Sunayana N, Raghavendra VB, Madhu CS, Shanmuganathan R, Brindhadevi K. Biogenic synthesis of gold nanoparticles using Commiphora wightii and their cytotoxic effects on breast cancer cell line (MCF-7). Process Biochem. 2020;92:269-276. https://doi.org/10.1016/j.procbio.2020.01.019.
31. Jeyarani S, Vinita NM, Puja P, Senthamilselvi S, Devan U, Velangani AJ, Biruntha M, Pugazhendhi A, Kumar P. Biomimetic gold nanoparticles for its cytotoxicity and biocompatibility evidenced by fluorescence-based assays in cancer (MDA-MB-231) and non-cancerous (HEK-293) cells. J Photochem Photobiol B. 2020;202:111715. https://doi.org/10.1016/j.jphotobiol.2019.111715.
32. Nirmala JG, Akila S, Narendhirakannan RT, Chatterjee S. Vitis vinifera peel polyphenols stabilized gold nanoparticles induce cytotoxicity and apoptotic cell death in A431 skin cancer cell lines. Adv Powder Technol. 2017;28(4):1170-1184. https://doi.org/10.1016/j.apt.2017.02.003.
33. Blom van Staden A, Kovacs D, Cardinali G, Picardo M, Lebeko M, Khumalo NC, Ray SS, Lall N. Synthesis and characterization of gold nanoparticles biosynthesised from Aspalathus linearis (Burm.f.) R.Dahlgren For progressive macular hypomelanosis. J Herb Med. 2021;29:100481. https://doi.org/10.1016/j.hermed.2021.100481.
34. Vimalraj S, Ashokkumar T, Saravanan S. Biogenic gold nanoparticles synthesis mediated by Mangifera indica seed aqueous extracts exhibits antibacterial, anticancer and anti-angiogenic properties. Biomed Pharmacother. 2018;105:440-448. https://doi.org/10.1016/j.biopha.2018.05.151.
35. Huo Y, Singh P, Kim YJ, Soshnikova V, Kang J, Markus J, Ahn S, Castro-Aceituno V, Mathiyalagan R, Chokkalingam M, Bae K, Yang DC. Biological synthesis of gold and silver chloride nanoparticles by Glycyrrhiza uralensis and in vitro applications. Artif Cells Nanomed Biotechnol. 2018;46(2):303-312. https://doi.org/10.1080/21691401.2017.1307213.
36. El-Borady OM, Ayat MS, Shabrawy MA, Millet P. Green synthesis of gold nanoparticles using Parsley leaves extract and their applications as an alternative catalytic, antioxidant, anticancer and antibacterial agents. Adv Powder Technol. 2020;31(10):4390-4400. https://doi.org/10.1016/j.apt.2020.09.017.
37. Liu Q, Wu F, Chen Y, Alrashood ST, Alharbi SA. Anti-human colon cancer properties of a novel chemotherapeutic supplement formulated by gold nanoparticles containing Allium sativum L. leaf aqueous extract and investigation of its cytotoxicity and antioxidant activities. Arab J Chem. 2021;14(4):103039. https://doi.org/10.1016/j.arabjc.2021.103039.
38. Jiménez Pérez ZE, Mathiyalagan R, Markus J, Kim YJ, Kang HM, Abbai R, Seo KH, Wang D, Soshnikova V, Yang DC. Ginseng-berry-mediated gold and silver nanoparticle synthesis and evaluation of their in vitro antioxidant, antimicrobial and cytotoxicity effects on human dermal fibroblast and murine melanoma skin cell lines. Int J Nanomedicine. 2017;12:709-723. https://doi.org/10.2147/IJN.S118373.
39. Ke Y, Al Aboody MS, Alturaiki W, Alsagaby SA, Alfaiz FA, Veeraraghavan VP, Mickymaray S. Photosynthesized gold nanoparticles from Catharanthus roseus induces caspase-mediated apoptosis in cervical cancer cells (HeLa). Artif Cells Nanomed Biotechnol. 2019;47(1):1938-1946. https://doi.org/10.1080/21691401.2019.1614017.
40. Chen J, Li Y, Fang G, Cao Z, Shang Y, Alfarraj S, Alharbi SA, Li J, Yang S, Duan X. Green synthesis, characterization, cytotoxicity, antioxidant and anti-human ovarian cancer activities of Curcumae kwangsiensis leaf aqueous extract green-synthesized gold nanoparticles. Arab J Chem. 2021;14(3):103000. https://doi.org/10.1016/j.arabjc.2021.103000.
41. Reyes-Becerril M, Ruvalcaba F, Sanchez V, López MG, Silva-Jara J, Hernandez-Adame L, Angulo C. Green synthesis of gold nanoparticles using Turnera diffusa Willd enhanced antimicrobial properties and immune response in Longfin yellowtail leukocytes. Aquac Res. 2021;52:3391-3402. https://doi.org/10.1111/are.15184.
42. Li. S, Al-Misned FA, El-Serehy HA, Yang L. Green synthesis of gold nanoparticles using aqueous extract of Mentha Longifolia leaf and investigation of its anti-human breast carcinoma properties in the in vitro condition. Arab J Chem. 2021;14(2):102931. https://doi.org/10.1016/j.arabjc.2020.102931.
43. Rajan A, Rajan AR, Philip D. Elettaria cardamomum seed mediated rapid synthesis of gold nanoparticles and its biological activities. OpenNano. 2017;2:1-8. https://doi.org/10.1016/j.onano.2016.11.002.
44. Yun Z, Chinnathambi A, Alharbi SA, Jin Z. Biosynthesis of gold nanoparticles using Vetex negundo and evaluation of pro-apoptotic effect on human gastric cancer cell lines. J Photochem Photobiol B: Biol. 2020;203:111749. https://doi.org/10.1016/j.jphotobiol.2019.111749.
45. Umapathi A, Navya PN, Madhyastha H, Singh M, Madhyastha R, Maruyama M, Daima HK. Curcumin and isonicotinic acid hydrazide functionalized gold nanoparticles for selective anticancer action. Colloids Surf A: Physicochem Eng Asp. 2020;607:125484. https://doi.org/10.1016/j.colsurfa.2020.125484.
46. Hoshyar R, Khayati GR, Poorgholami M, Kaykhaii M. A novel green one-step synthesis of gold nanoparticles using crocin and their anti-cancer activities. J Photochem Photobiol B. 2016;159:237-42. https://doi.org/10.1016/j.jphotobiol.2016.03.056.
47. Singh N, Das MK, Ansari A, Mohanta D, Rajamani P. Biogenic nanosized gold particles: Physico-chemical characterization and its anticancer response against breast cancer. Biotechnol Rep. 2021;30:e00612. https://doi.org/10.1016/j.btre.2021.e00612.
48. Sharma B, Deswal R. Single pot synthesized gold nanoparticles using Hippophae rhamnoides leaf and berry extract showed shape-dependent differential nanobiotechnological applications. Artif Cells Nanomed Biotechnol. 2018;46(sup2):408-418. https://doi.org/10.1080/21691401.2018.1458034.
49. Pechyen C, Ponsanti K, Tangnorawich B, Ngernyuang N. Waste fruit peel – Mediated green synthesis of biocompatible gold nanoparticles. J Mater Res Technol. 2021;14:2982-2991. https://doi.org/10.1016/j.jmrt.2021.08.111.
50. Chang Y, Zheng C, Chinnathambi A, Alahmadi TA, Alharbi SA. Cytotoxicity, anti-acute leukemia and antioxidant properties of gold nanoparticles green-synthesized using Cannabis sativa L leaf aqueous extract. Arab J Chem. 2021;14(4):103060. https://doi.org/10.1016/j.arabjc.2021.103060.
51. Sunderam V, Thiyagarajan D, Lawrence AV, Mohammed SSS, Selvaraj A. In-vitro antimicrobial and anticancer properties of green synthesized gold nanoparticles using Anacardium occidentale leaves extract. Saudi J Biol Sci. 2019;26(3):455-459. https://doi.org/10.1016/j.sjbs.2018.12.001.
52. Zhang X, Tan Z, Jia K, Zhang W, Dang M. Rabdosia rubescens Linn: green synthesis of gold nanoparticles and their anticancer effects against human lung cancer cells A549. Artif Cells Nanomed Biotechnol. 2019;47(1):2171-2178. https://doi.org/10.1080/21691401.2019.1620249.
53. Park SY, Kim B, Cui Z, Park G, Choi YW. Anti-Metastatic Effect of Gold Nanoparticle-Conjugated Maclura tricuspidata Extract on Human Hepatocellular Carcinoma Cells. Int J Nanomedicine. 2020;15:5317-5331. https://doi.org/10.2147/IJN.S246724.
54. Seetharaman P, Chandrasekaran R, Gnanasekar S, Mani I, Sivaperumal S. Biogenic gold nanoparticles synthesized using Crescentia cujete L. and evaluation of their different biological activities. Biocatal Agric Biotechnol. 2017;11:75-82. https://doi.org/10.1016/j.bcab.2017.06.004.
55. Imran M, Husseini G, Awad N, Paul V, El-Haj BM, Ali HS. An Effective Anticancer Nano-approach for Melanoma and Breast Cancers Using Annona muricata Gold Nanoparticles. Acta Sci Pharm Sci. 2021;5(9):46-54. https://doi.org/10.31080/ASPS.2021.05.0782.
56. Vemuri SK, Banala RR, Mukherjee S, Uppula P, Gpv S, A V GR, T M. Novel biosynthesized gold nanoparticles as anti-cancer agents against breast cancer: Synthesis, biological evaluation, molecular modelling studies. Mater Sci Eng C Mater Biol Appl. 2019;99:417-429. https://doi.org/10.1016/j.msec.2019.01.123.
57. Chahardoli A, Karimi N, Fattahi A, Salimikia I. Biological applications of phytosynthesized gold nanoparticles using leaf extract of Dracocephalum kotschyi. J Biomed Mater Res A. 2019;107(3):621-630. https://doi.org/10.1002/jbm.a.36578.
58. Nagalingam M, Kalpana VN, Rajeswari VD, Panneerselvam A. Biosynthesis, characterization and evaluation of bioactivities of leaf extract-mediated biocompatible gold nanoparticles from Alternanthera bettzickiana. Biotechnol Rep. 2018;19:e00268. https://doi.org/10.1016/j.btre.2018.e00268.
59. Patil MP, Bayaraa E, Subedi P, Piad LLA, Tarte NH, Kim GD. Biogenic synthesis, characterization of gold nanoparticles using Lonicera japonica and their anticancer activity on HeLa cells. J Drug Deliv Sci Technol. 2019;51:83-90. https://doi.org/10.1016/j.jddst.2019.02.021.
60. Dhayalan M, Denison MIJ, Ayyar M, Gandhi NN, Krishnan K, Abdulhadi B. Biogenic synthesis, characterization of gold and silver nanoparticles from Coleus forskohlii and their clinical importance. J Photochem Photobiol B: Biol. 2018;183:251-257. https://doi.org/10.1016/j.jphotobiol.2018.04.042.
61. Chokkalingam M, Singh P, Huo Y, Soshnikova V, Ahn S, Kang J, Mathiyalagan R, Kim YJ, Yang DC. Facile synthesis of Au and Ag nanoparticles using fruit extract of Lycium chinense and their anticancer activity. J Drug Deliv Sci Technol. 2019;49:308-315. https://doi.org/10.1016/j.jddst.2018.11.025.
62. Hamelian M, Varmira K, Veisi H. Green synthesis and characterizations of gold nanoparticles using Thyme and survey cytotoxic effect, antibacterial and antioxidant potential. J Photochem Photobiol B. 2018;184:71-79. https://doi.org/10.1016/j.jphotobiol.2018.05.016.
63. Boomi P, Ganesan RM, Poorani G, Gurumallesh Prabu H, Ravikumar S, Jeyakanthan J. Biological synergy of greener gold nanoparticles by using Coleus aromaticus leaf extract. Mater Sci Eng C Mater Biol Appl. 2019;99:202-210. https://doi.org/10.1016/j.msec.2019.01.105.
64. Kumar PS, Jeyalatha MV, Malathi J, Ignacimuthu S. Anticancer effects of one-pot synthesized biogenic gold nanoparticles (Mc-AuNps) against laryngeal carcinoma. J Drug Deliv Sci Technol. 2018;44:118-128. https://doi.org/10.1016/j.jddst.2017.12.008.
65. Balashanmugam P, Durai P, Balakumaran MD, Kalaichelvan PT. Phytosynthesized gold nanoparticles from C. roxburghii DC. leaf and their toxic effects on normal and cancer cell lines. J Photochem Photobiol B: Biol. 2016;165:163-173. https://doi.org/10.1016/j.jphotobiol.2016.10.013.
66. Balasubramanian S, Kala SMJ, Pushparaj TL. Biogenic synthesis of gold nanoparticles using Jasminum auriculatum leaf extract and their catalytic, antimicrobial and anticancer activities. J Drug Deliv Sci Technol. 2020;57:101620. https://doi.org/10.1016/j.jddst.2020.101620.
67. Godipurge SS, Yallappa S, Biradar NJ, Biradar JS, Dhananjaya BL, Hegde G, Jagadish K, Hegde G. A facile and green strategy for the synthesis of Au, Ag and Au–Ag alloy nanoparticles using aerial parts of R. hypocrateriformis extract and their biological evaluation. Enzyme Microb Technol. 2016;95:174-184. https://doi.org/10.1016/j.enzmictec.2016.08.006.
68. Vijayakumar S, Vaseeharan B, Malaikozhundan B, Gopi N, Ekambaram P, Pachaiappan R, Velusamy P, Murugan K, Benelli G, Suresh Kumar R, Suriyanarayanamoorthy M. Therapeutic effects of gold nanoparticles synthesized using Musa paradisiaca peel extract against multiple antibiotic resistant Enterococcus faecalis biofilms and human lung cancer cells (A549). Microb Pathog. 2017;102:173-183. https://doi.org/10.1016/j.micpath.2016.11.029.
69. Naraginti S, Li Y. Preliminary investigation of catalytic, antioxidant, anticancer and bactericidal activity of green synthesized silver and gold nanoparticles using Actinidia deliciosa. J Photochem Photobiol B: Biol. 2017;170:225-234. https://doi.org/10.1016/j.jphotobiol.2017.03.023.
70. Satpathy S, Patra A, Ahirwar B, Hussain MD. Process optimization for green synthesis of gold nanoparticles mediated by extract of Hygrophila spinosa T. Anders and their biological applications. Phys E: Low-dimens Syst Nanostructures. 2020;121:113830. https://doi.org/10.1016/j.physe.2019.113830.
71. Karthika V, Arumugam A, Gopinath K, Kaleeswarran P, Govindarajan M, Alharbi NS, Kadaikunnan S, Khaled JM, Benelli G. Guazuma ulmifolia bark-synthesized Ag, Au and Ag/Au alloy nanoparticles: Photocatalytic potential, DNA/protein interactions, anticancer activity and toxicity against 14 species of microbial pathogens. J Photochem Photobiol B: Biol. 2017;167:189-199. https://doi.org/10.1016/j.jphotobiol.2017.01.008.
72. Sun B, Hu N, Han L, Pi Y, Gao Y, Chen K. Anticancer activity of green synthesised gold nanoparticles from Marsdenia tenacissima inhibits A549 cell proliferation through the apoptotic pathway. Artif Cells Nanomed Biotechnol. 2019;47(1):4012-4019. https://doi.org/10.1080/21691401.2019.1575844.
73. Wang L, Xu J, Yan Y, Liu H, Li F. Synthesis of gold nanoparticles from leaf Panax notoginseng and its anticancer activity in pancreatic cancer PANC-1 cell lines. Artif Cells Nanomed Biotechnol. 2019;47(1):1216-1223. https://doi.org/10.1080/21691401.2019.1593852.
74. Patil MP, Jin X, Simeon NC, Palma J, Kim D, Ngabire D, Kim NH, Tarte NH, Kim GD. Anticancer activity of Sasa borealis leaf extract-mediated gold nanoparticles. Artif Cells Nanomed Biotechnol. 2017;46(1):82-88. https://doi.org/10.1080/21691401.2017.1293675.
75. Wu T, Duan X, Hu C, Wu C, Chen X, Huang J, Liu J, Cui S. Synthesis and characterization of gold nanoparticles from Abies spectabilis extract and its anticancer activity on bladder cancer T24 cells. Artif Cells Nanomed Biotechnol. 2019;47(1):512-523. https://doi.org/10.1080/21691401.2018.1560305.
76. Kuppusamy P, Ichwan SJA, Al-Zikri PNH, Suriyah WH Soundharrajan I, Govindan N, Maniam GP, Yusoff MM. In Vitro Anticancer Activity of Au, Ag Nanoparticles Synthesized Using Commelina nudiflora L. Aqueous Extract Against HCT-116 Colon Cancer Cells. Biol Trace Elem Res. 2016;173:297–305. https://doi.org/10.1007/s12011-016-0666-7.
77. Castro-Aceituno V, Abbai R, Moon SS, Ahn S, Mathiyalagan R, Kim YJ, Kim YJ, Yang DC. Pleuropterus multiflorus (Hasuo) mediated straightforward eco-friendly synthesis of silver, gold nanoparticles and evaluation of their anti-cancer activity on A549 lung cancer cell line. Biomed Pharmacother. 2017;93:995-1003. https://doi.org/10.1016/j.biopha.2017.07.040.
78. Divakaran D, Lakkakula JR, Thakur M, Kumawat MK, Srivastava R. Dragon fruit extract capped gold nanoparticles: Synthesis and their differential cytotoxicity effect on breast cancer cells. Mater Lett.2019;236:498-502. https://doi.org/10.1016/j.matlet.2018.10.156.
79. Wu F, Zhu J, Li G, Wang L, Veeraraghavan VP, Mohan SK, Zhang Q. Biologically synthesized green gold nanoparticles from Siberian ginseng induce growth-inhibitory effect on melanoma cells (B16). Artif Cells Nanomed Biotechnol. 2019;47(1):3297-3305, https://doi.org/10.1080/21691401.2019.1647224.
80. Elemike EE, Onwudiwe DC, Nundkumar N, Singh M, Iyekowa O. Green synthesis of Ag, Au and Ag-Au bimetallic nanoparticles using Stigmaphyllon ovatum leaf extract and their in vitro anticancer potential. Mater Lett. 2019;243:148-152. https://doi.org/10.1016/j.matlet.2019.02.049.
81. Barai AC, Paul K, Dey A, et al. Green synthesis of Nerium oleander-conjugated gold nanoparticles and study of its in vitro anticancer activity on MCF-7 cell lines and catalytic activity. Nano Converg. 2018;5(1):10. https://doi.org/10.1186/s40580-018-0142-5.
82. Zangeneh MM, Zangeneh A. Novel green synthesis of Hibiscus sabdariffa flower extract conjugated gold nanoparticles with excellent anti-acute myeloid leukemia effect in comparison to daunorubicin in a leukemic rodent model. Appl Organometal Chem. 2020;34:e5271. https://doi.org/10.1002/aoc.5271.
83. Wang L, Xu J, Yan Y, Liu H, Karunakaran T, Li F. Green synthesis of gold nanoparticles from Scutellaria barbata and its anticancer activity in pancreatic cancer cell (PANC‐1). Artif Cells Nanomed Biotechnol. 2019;47(1):1617-1627. https://doi.org/10.1080/21691401.2019.1594862.
84. Lee YJ, Ahn EY, Park Y. Shape-dependent cytotoxicity and cellular uptake of gold nanoparticles synthesized using green tea extract. Nanoscale Res Lett. 2019;14:129. https://doi.org/10.1186/s11671-019-2967-1.
85. Fanoro OT, Parani S, Maluleke R, Lebepe TC, Varghese JR, Mavumengwana V, Oluwafemi OS. Facile Green, Room-Temperature Synthesis of Gold Nanoparticles Using Combretum erythrophyllum Leaf Extract: Antibacterial and Cell Viability Studies against Normal and Cancerous Cells. Antibiotics.2021;10:893. https://doi.org/10.3390/antibiotics10080893.
86. Foo YY, Periasamy V, Kiew LV, Kumar GG, Malek SNA. Curcuma mangga-Mediated Synthesis of Gold Nanoparticles: Characterization, Stability, Cytotoxicity and Blood Compatibility. Nanomaterials. 2017; 7(6):123. https://doi.org/10.3390/nano7060123.
87. Tiloke C, Phulukdaree A, Anand K, Gengan RM, Chuturgoon AA. Moringa oleifera Gold Nanoparticles Modulate Oncogenes, Tumor Suppressor Genes and Caspase-9 Splice Variants in A549 Cells. J Cell Biochem. 2016;117:2302-2314. https://doi.org/10.1002/jcb.25528.
88. Mukundan D, Mohankumar R, Vasanthakumari R. Comparative study of synthesized silver and gold nanoparticles using leaves extract of Bauhinia tomentosa Linn and their anticancer efficacy. Bull Mater Sci. 2017;40:335–344. https://doi.org/10.1007/s12034-017-1376-2.
89. Rajakumar G, Gomathi T, Abdul Rahuman A, Thiruvengadam M, Mydhili G, Kim S-H, Lee T-J, Chung I-M. Biosynthesis and Biomedical Applications of Gold Nanoparticles Using Eclipta prostrata Leaf Extract. Appl Sci. 2016;6(8):222. https://doi.org/10.3390/app6080222.
90. Ghramh HA, Khan KA, Ibrahim EH, Setzer WN. Synthesis of Gold Nanoparticles (AuNPs) Using Ricinus communis Leaf Ethanol Extract, Their Characterization and Biological Applications. Nanomaterials. 2019;9(5):765. https://doi.org/10.3390/nano9050765.
91. Singh H, Du J, Singh P, Yi TH. Ecofriendly synthesis of silver and gold nanoparticles by Euphrasia officinalis leaf extract and its biomedical applications. Artif Cells Nanomed Biotechnol. 2017;46(6):1163-1170. https://doi.org/10.1080/21691401.2017.1362417.
92. Hemmati S, Joshani Z, Zangeneh A, Zangeneh MM. Green synthesis and chemical characterization of Thymus vulgaris leaf aqueous extract conjugated gold nanoparticles for the treatment of acute myeloid leukemia in comparison to doxorubicin in a leukemic mouse model. Appl Organometal Chem. 2020;34:e5267. https://doi.org/10.1002/aoc.5267.
93. Lee YJ, Song K, Cha S-H, Cho S, Kim YS, Park Y. Sesquiterpenoids from Tussilago farfara Flower Bud Extract for the Eco-Friendly Synthesis of Silver and Gold Nanoparticles Possessing Antibacterial and Anticancer Activities. Nanomaterials. 2019;9(6):819. https://doi.org/10.3390/nano9060819. .
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How to Cite
Raju, S. K., P. Sekar, S. Kumar, M. Murugesan, and M. Karthikeyan. “PLANT-MEDIATED GREEN SYNTHESIS OF GOLD NANOPARTICLES AND THEIR ANTICANCER APPLICATIONS: AN UPDATED REVIEW”. Journal of Applied Pharmaceutical Sciences and Research, Vol. 4, no. 4, Mar. 2022, pp. 1-20, doi:10.31069/japsr.v4i4.1.
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