FORMULATION, DEVELOPMENT AND EVALUATION OF COMPRESSED-COATED TABLET FOR THE TREATMENT OF DIABETES MELLITUS

Abstract

Tablets are the most widely utilized solid dosage form for oral drug delivery due to their stability, convenience, and patient compliance. Among advanced drug delivery systems, modified release formulations have gained considerable attention for their ability to optimize therapeutic efficacy and reduce dosing frequency. Compression coating technology, a solvent-free and versatile approach, has emerged as an effective method for developing such systems. Compression-coated tablets, also known as tablet-in-tablet systems, consist of two distinct layers: an inner core and an outer coating. In the present study, a novel compression-coated tablet was designed wherein the inner core provides immediate drug release, while the outer layer is formulated to achieve extended release. The core tablet, prepared as a porous structure, ensures rapid drug release to provide an initial therapeutic effect. The formulation process involves precise positioning of the preformed core tablet within a die partially filled with coating material, followed by addition of the remaining coating powder and compression to form a uniform tablet. However, challenges such as core alignment and mechanical integrity must be carefully addressed during formulation. The developed formulation was evaluated for pre-compression and post-compression parameters, drug content uniformity, and in vitro drug release studies to assess its performance. The results demonstrate that the compression-coated tablet successfully achieves the desired drug release profile, making it a promising approach for combination therapy and controlled drug delivery applications.