PREVENTIVE EFFECT OF PHASEOLUS VULGARIS SEED COATS ON PENTYLENETETRAZOLE (PTZ) INDUCED KINDLING AND BEHAVIORAL COMORBIDITIES

  • Sarika Chaudhary Department of Pharmacology, I. T. S College of Pharmacy, Muradnagar, Ghaziabad, India, 201206,
  • Sagarika Majhi Department of Pharmacology, I. T. S College of Pharmacy, Muradnagar, Ghaziabad, India, 201206,
  • Madhu Verma Department of Pharmacology, I. T. S College of Pharmacy, Muradnagar, Ghaziabad, India, 201206,

Abstract

Introduction: To investigate the preventive effect of Phaseolus vulgaris seed coats on pentylenetetrazole-induced kindling and behavioral comorbidities. Material and Methods: Thirty Wistar albino rats were categorized into five groups. The first group received regular saline (0.9 % w/v NaCl) p.o.; the second group received PTZ (35 mg/kg b.w.) i.p.; the third group received valproic acid (200 mg/kg b.w.) p.o.; the fourth group received P. vulgaris extract (100 mg/kg b.w.) p.o.; the fifth group received P. vulgaris extract (200 mg/kg b.w.) p.o. on an alternate day for 21 days. PTZ improved lipid peroxidase levels, decreased Glutathione level, decreased superoxide dismutase activity, increased Nitric Oxide level. Result: This study revealed that P. vulgaris (Hydroalcoholic extract) increased the anti-oxidant level of both 100 mg/kg and 200 mg/kg compared to the PTZ category. Histopathological findings revealed that the hippocampal section of the brain of rats receiving P. vulgaris extract had improved relative to the receiving PTZ group. Conclusion: Based on the result, it is proposed that Phaseolus vulgaris has anti-oxidant properties. This is useful for the treatment of epilepsy.

Keywords: Phaseolus vulgaris, Epilepsy, Kindling, Oxidative stress, Pentylenetetrazole

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How to Cite
Chaudhary, S., S. Majhi, and M. Verma. “PREVENTIVE EFFECT OF PHASEOLUS VULGARIS SEED COATS ON PENTYLENETETRAZOLE (PTZ) INDUCED KINDLING AND BEHAVIORAL COMORBIDITIES”. Journal of Applied Pharmaceutical Sciences and Research, Vol. 3, no. 4, Jan. 2021, pp. 20-25, doi:10.31069/japsr.v3i4.4.
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Research Articles